Reduction of circulating methylglyoxal levels by a Mediterranean diet is associated with preserved kidney function in patients with type 2 diabetes and coronary heart disease: From the CORDIOPREV randomized controlled trial
Authors' conclusion
Our study showed that lowering circulating AGE levels, specifically MG, after following a Mediterranean diet, might be linked to the preservation of kidney function, evidenced by a decreased decline of eGFR in T2DM patients with CHD. Patients with mildly decreased eGFR could potentially benefit more from AGE reduction in maintaining kidney function.
Study context
- Population
- T2D patients with coronary heart disease and estimated glomerular filtration rate (eGFR) ≥ 30 ml/min/1.73 m², classified by baseline kidney function: normal eGFR (≥ 90), mildly decreased (60- < 90) and moderately decreased (<60 ml/min/1.73 m²)of 1002 in CORDIOPREV
- Participants
- 540 patients
- Comparison
- Mediterranean diet vs low-fat diet
- Primary endpoint
- eGFR decline
- Follow-up
- 5-years of dietary intervention
Primary result
As reported in the abstract
5 years
- Lower eGFR decline with Mediterranean diet vs low-fat diet only in patients with mildly decreased eGFR
- Mediterranean diet vs Low-fat diet: P = 0.035
Further findings
Methylglyoxal (MG) levels and GloxI expression in normal and mildly decreased eGFR
- Mediterranean diet decreased MG levels and increased GloxI expression in normal and mildly decreased eGFR patients
- all P < 0.05
Association of MG levels after intervention with eGFR decline
- Per 1 SD increment of MG levels after intervention, probability of eGFR decline
- 6.8-fold higher (95 % CI 0.039;0.554)
Original publication
Reduction of circulating methylglyoxal levels by a Mediterranean diet is associated with preserved kidney function in patients with type 2 diabetes and coronary heart disease: From the CORDIOPREV randomized controlled trial. Diabetes Metab. Published 12 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →