Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link?
Authors' conclusion
Serum Ism-1 levels were inversely associated with eGFR, and high Ism-1 levels may be used as a potential biomarker for predicting kidney function impairment in patients with T2DM.
Study context
- Population
- Patients with T2D
- Participants
- 209 patients
- Exposure
- Decreased estimated glomerular filtration rate (eGFR) vs normal eGFR
- Decreased eGFRn = 42
- Normal eGFRn = 167reference
- Outcome
- Relationship between serum isthmin-1 (Ism-1) levels and glomerular filtration rate (GFR)
Main finding
As reported in the abstract
Serum Ism-1 and eGFR
OR of eGFR <60 mL/min/1.73 m² per 0.1 ng/mL increment of Ism-1 (p<0.001)
1.545
ROC: AUC of Ism-1 >1.297 ng/mL for eGFR <60 mL/min/1.73 m²
0.908
Observational data: associations, not effects.
Original publication
Glomerular filtration rate in patients with type 2 diabetes mellitus: is serum isthmin-1 level a possible link? BMJ Open Diabetes Res Care. Published 28 August 2023. doi:10.
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