Recovery of BMD after pregnancy and breastfeeding—a 10-yr prospective observational study of 25-yr-old women
Authors' conclusion
In conclusion and despite repeated fluctuations in BMD resulting from the physiological demands of multiple pregnancies and periods of breastfeeding, BMD recovers and ultimately does not differ from that of identically aged women without children.
Study context
- Population
- Women of the PEAK-25 cohort, all aged 25 at inclusion and 35 at follow-up, nulliparous at baseline
- Participants
- 573 vs 177
- Exposure
- Parous vs nulliparous women at age 35
- Parousn = 573
- Nulliparousn = 177reference
- Outcome
- BMD and BMD fluctuations from parity and lactation
- Follow-up
- Age 35 (10 yr)
Methodological details10-yr follow-up
- 10-yr follow-up
Main finding
Spine BMD at age 35
Difference
2.1 %
P = 0.043
As reported in the abstract
Observational data: associations, not effects.
Further findings
FN BMD by time from weaning to DXA · lower FN BMD with weaning within 6 mo
P < 0.001
| Outcome | Difference (%) | P value |
|---|---|---|
| TH BMD, pregnant within 12 mo vs more than 36 moLower with pregnancy within 12 mo | 4 | P = 0.054, padjusted = .032 |
BMD change from age 25 to 35, whole cohort · 10 yr
- FN BMD change
- −3.4%
- TH BMD change
- −2.7%
- Spine BMD change
- 0.9%
BMD in women pregnant <24 mo vs >24 mo before DXA
- FN BMD lowest in more recently pregnant
- −2.2%
- TH BMD lowest in more recently pregnant
- −2.7%
BMD with cumulative breastfeeding beyond 15 mo
- FN BMD change
- −4.3%
- TH BMD change
- −3.7%
- Lower spine BMD accretion
Original publication
Recovery of BMD after pregnancy and breastfeeding—a 10-yr prospective observational study of 25-yr-old women. J Bone Miner Res. Published 24 June 2025. doi:10.
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