RBP4-based Multimarker Score: A Prognostic Tool for Adverse Cardiovascular Events in Acute Coronary Syndrome Patients
Authors' conclusion
The RBP4-derived 5-item score serves as a useful risk stratification and decision support for secondary prevention in patients with ACS.
Study context
- Population
- Patients with acute coronary syndrome (ACS), department of cardiology; score: 1 point each for RBP4 ≥ 38.18μg/mL, LVEF ≤ 55%, NT-proBNP ≥ 450 ng/L, eGFR ≤ 90 mL/min/1.73 m², age ≥60
- Participants
- 826 patients
- Exposure
- RBP4-based multimarker score categories
- Score 0-1n = 315reference
- Score 2-3n = 406
- Score 4-5n = 105
- Outcome
- MACE
- Follow-up
- Median 1.95 years (IQR 1.02-3.25 years)
Methodological detailsconsecutively recruited, single department
- Consecutively recruited
- Single department
Main finding
As reported in the abstract
MACE by RBP4-based multimarker score
Each group vs score 0-1Adjusted hazard ratio (95% CI)
Score 2-3
1.80(1.34–2.41)
Score 4-5
3.26(2.21–4.81)
- Significant graded association between score and MACE risk and its components
- P < 0.05 for each
- MACE overall
- 269 (32.57%)
Observational data: associations, not effects.
Further findings
High-risk anatomical or clinical subgroups
- Prognostic and discriminative value of the score remained robust in ACS patients with various high-risk anatomical or clinical characteristics
Original publication
RBP4-based Multimarker Score: A Prognostic Tool for Adverse Cardiovascular Events in Acute Coronary Syndrome Patients. J Clin Endocrinol Metab. Published 4 July 2023. doi:10.
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