Development of Spinal Enthesopathies in Adults With X-linked Hypophosphatemia
Authors' conclusion
This study confirms the high proportion of patients with a progression of spinal enthesopathies. Age seems to be the main factor associated with progression.
Study context
- Population
- Adults with X-linked hypophosphatemia (XLH) with 2 EOS imaging ≥2 years apart at the French Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, June 2011–March 202266.7% women
- Participants
- 51 adults
- Outcome
- Progression of spinal enthesopathies (new enthesopathy at ≥1 intervertebral level) and its association with demographics, treatment and PHEX mutation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Progression of spinal enthesopathies · mean interval 5.7 (± 2.31) years
- Patients with progression
- 27 (52.9%)
- Univariate: progression associated with older age
- P < .0005
- Univariate: older at treatment initiation
- P = .02
- Univariate: dental complications
- P = .03
- Univariate: less frequent childhood treatment with phosphate and/or vitamin D analogs
- P = .06
- Univariate: more frequent hip osteoarthritis at baseline
- P = .002
Observational data: associations, not effects.
Original publication
Development of Spinal Enthesopathies in Adults With X-linked Hypophosphatemia. J Clin Endocrinol Metab. Published 30 June 2023. doi:10.
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