Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity
Authors' conclusion
Pathogenic variants in MC4R are associated with increased VAT, HFF%, and insulin resistance, independent from the degree of obesity in youth.
Study context
- Population
- Youth (6–21 years) with overweight/obesity, Yale Pediatric Obesity Clinic, New Haven, CT
- Participants
- 877 participants
- Exposure
- MC4R Pathogenic Variant vs No Pathogenic Variant
- Outcome
- Oral glucose tolerance test (OGTT) glucose, insulin, insulin sensitivity; abdominal MRI fat
Methodological detailssingle-centre, genetic screening
- Single-centre
- Genetic screening
Main finding
As reported in the abstract
- Pathogenic Variant vs No Pathogenic Variant: P = 0.001
- Pathogenic Variant vs No Pathogenic Variant: P = 0.002
- Pathogenic Variant vs No Pathogenic Variant: P = 0.0008
- Pathogenic Variant vs No Pathogenic Variant: P = 0.003
- Pathogenic Variant vs No Pathogenic Variant: P = 0.012
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| BMI z-score, SAT, total body fatPathogenic Variant vs No Pathogenic Variant · similar | P = 0.255 |
| BMI z-score, SAT, total body fatPathogenic Variant vs No Pathogenic Variant · similar | P = 0.643 |
| BMI z-score, SAT, total body fatPathogenic Variant vs No Pathogenic Variant · similar | P = 0.225 |
Original publication
Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity. Int J Obes (Lond). Published 29 December 2024. doi:10.
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