Increased copeptin may reflect vasopressin‐related metabolic changes after bariatric surgery
Authors' conclusion
Increases in copeptin after weight loss in MBS compared with NS were associated with lower REE and higher HbA1c/HOMA-IR values. Vasopressin may contribute to MBS-related metabolic modifications.
Study context
- Population
- Youth with obesity (78% female; mean age 18.7 [SD 2.8] y; mean BMI 45.6 [SD 6.8] kg/m²)
- Participants
- 64 participants
- Exposure
- Metabolic and bariatric surgery (MBS) vs nonsurgical lifestyle management
- MBSn = 34
- Nonsurgical (NS)n = 30reference
- Outcome
- Copeptin changes following MBS and associations with metabolic parameters
- Follow-up
- 12 months
Methodological details12-month
- 12-month
Main finding
As reported in the abstract
Fasting copeptin change
- MBS vs NS: time-by-treatment p = 0.017
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| HbA1c and adiposity change · 12 monthsDecreased more after MBS | ps ≤ 0.036 |
Correlations of copeptin changes, whole group · 12 months
- Negative correlation with % fat mass and resting energy expenditure (REE) changes (ps ≤ 0.025)
- rho ≤ −0.29
Correlations of copeptin changes, MBS · 12 months
- Positive correlation with hemoglobin A1c (HbA1c) and homeostatic model assessment for insulin resistance (HOMA-IR) (false discovery rate-adjusted p = 0.05)
- rho ≥ 0.41
- Negative correlation with REE changes (false discovery rate-adjusted p = 0.036)
- rho = −0.55
Original publication
Increased copeptin may reflect vasopressin‐related metabolic changes after bariatric surgery. Obesity (Silver Spring). Published 26 December 2024. doi:10.
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