Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-world Population-Based Study in Subjects With Type 2 Diabetes
Authors' conclusion
Our results suggest that the rapid reduction of HbA1c is not associated with progression of mild or moderate NPDR.
Study context
- Population
- Subjects with T2D and previous mild or moderate nonproliferative DR (NPDR), SIDIAP primary care databasematched case-control
- Participants
- 1,150 vs 1,150
- Comparison
- Early worsening of diabetic retinopathy (EWDR) cases vs matched controls
- EWDRn = 1,150
- Controln = 1,150reference
- Outcome
- Magnitude of HbA1c reduction; categorized as rapid (>1.5% in <12 months) or very rapid (>2% in <6 months)
- Follow-up
- Previous 12 months
Methodological detailspopulation-based, matched
- Population-based
- Matched
Main finding
As reported in the abstract
HbA1c reduction
EWDR
0.13
± 1.21
Controls
0.21
± 1.18
P = 0.12
Observational data: associations, not effects.
Further findings
Association of HbA1c reduction with worsening of DR
- No significant association, in unadjusted analyses or in models adjusted for diabetes duration, baseline HbA1c, hypertension and antidiabetic drugs
EWDR risk by baseline HbA1c strata
- Patients with higher HbA1c did not show a higher risk of EWDR
Original publication
Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-world Population-Based Study in Subjects With Type 2 Diabetes. Diabetes Care. Published 10 July 2023. doi:10.
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