A Randomized Controlled Trial Assessing the Impact of Continuous Glucose Monitoring with a Predictive Hypoglycemia Alert Function on Hypoglycemia in Physical Activity for People with Type 1 Diabetes (PACE)
Authors' conclusion
A CGM device with an ULS alert reduces exposure to hypoglycemia below 2.8 mmol/L overall and in the 24 h after exercise compared with a threshold alert.
Study context
- Population
- People with T1D doing regular (≥150 min/week) physical activity8 men · 16 women
- Participants
- 24 people
- Comparison
- Continuous glucose monitoring (CGM) with urgent low soon (ULS) predictive alert on vs off
- Primary endpoint
- Frequency, duration and severity of hypoglycemia during and after physical activity
Methodological detailscrossover, blinded run-in
- Crossover
- Blinded run-in
Primary result
As reported in the abstract
Change from baseline of hypoglycemia <3.0 and <3.9 mmol/L · 24 h after exercise
- No difference in change from baseline of hypoglycemia <3.0 and <3.9 mmol/L with ULS on vs off
Further findings
| Outcome | P value |
|---|---|
| Time below 2.8 mmol/L vs baseline · 24 h after exerciseLower with ULS on | P = 0.04 |
Predictors of hypoglycemia (mixed effects regression)
- Exercise timing and baseline HbA1c independently affected hypoglycemia risk during exercise; exercise timing also affected risk after exercise
Original publication
A Randomized Controlled Trial Assessing the Impact of Continuous Glucose Monitoring with a Predictive Hypoglycemia Alert Function on Hypoglycemia in Physical Activity for People with Type 1 Diabetes (PACE). Diabetes Technol Ther. Published 27 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →