Clinical Efficacy Evaluation of a Continuous Glucose Monitoring-Guided Forecasting Algorithm to Mitigate Postbariatric Hypoglycemia: A Randomized Controlled Trial
Authors' conclusion
While a 5 g preventive dose was insufficient, these simulations indicate that CGM-guided hypoglycemia forecasting warrants evaluation as an approach for reducing postprandial hypoglycemia in individuals with PBH.
Study context
- Population
- Individuals with postbariatric hypoglycemia after RYGB undergoing a standardized meal test
- Participants
- 59 individuals
- Comparison
- 5 g glucose upon continuous glucose monitoring (CGM)-guided algorithm's predictive alert vs when plasma glucose <3.0 mmol/L
- Interventionn = 32
- Controln = 27reference
Primary result
As reported in the abstract
Hypoglycemia incidence (<3.0 mmol/L)
P = 0.30
Further findings
Nadir glucose and time below 3.9 and 3.0 mmol/L
- Did not differ significantly between groups
Extrapolation: 10 g preventive glucose dose
- Simulated hypoglycemia incidence with 10 g dose
- 9%
- Extrapolation based on previously published glucose dose-response data
Original publication
Clinical Efficacy Evaluation of a Continuous Glucose Monitoring-Guided Forecasting Algorithm to Mitigate Postbariatric Hypoglycemia: A Randomized Controlled Trial. Diabetes Technol Ther. Published 14 March 2026. doi:10.
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