Quality of life improvements associated with weight loss using a novel shape-shifting hydrogel capsule: RESET study results
An erratum to this article was published (Int J Obes (Lond), Mar 2026 ↗)
Authors' conclusion
The Epitomee capsule, with lifestyle intervention, is associated with IWQOL-Lite-CT improvement, highlighting its potential as an effective non-pharmaceutical adjunct to lifestyle intervention for enhancing health outcomes in individuals with overweight and obesity.
Study context
- Population
- Adults with overweight and obesity, BMI 27–40 kg/m²
- Participants
- 279 adults
- Comparison
- Epitomee capsule vs placebo, with lifestyle intervention
- Primary endpoint
- Change in IWQOL-Lite-CT scores (predefined QOL endpoints)
- Follow-up
- 24 weeks
Methodological detailsdouble-blind, placebo-controlled, predefined quality of life (QOL) endpoints and post hoc analyses
- Double-blind
- Placebo-controlled
- Predefined QOL endpoints and post hoc analyses
Primary result
As reported in the abstract
- Improved total IWQOL-Lite-CT score and Physical Function sub-score with Epitomee vs placebo
- Numerically higher improvements in Physical and Psychosocial sub-scores with Epitomee, not statistically significant
- Epitomee vs Placebo: P < 0.05
Further findings
Change from baseline in IWQOL-Lite-CT total score and Physical, Physical Function and Psychosocial sub-scores within each group · 24 weeks
- Both groups showed a significant improvement from baseline (p < 0.05)
Correlation between weight loss and QOL improvements
- Stronger correlation between weight loss and QOL improvements with Epitomee vs placebo
- Post hoc analyses
Original publication
Quality of life improvements associated with weight loss using a novel shape-shifting hydrogel capsule: RESET study results. Int J Obes (Lond). Published 16 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →