Psychiatric Comorbidities in Women With Complete Androgen Insensitivity Syndrome or Müllerian Duct Aplasia/Agenesis
Authors' conclusion
On balance, these findings are reassuring, albeit requiring confirmation in other settings. Future studies using longitudinal designs and patient-reported outcomes are needed to evaluate changes in mental health status of CAIS and MA patients at different ages and different intervals following initial diagnosis.
Study context
- Population
- All individuals with confirmed complete androgen insensitivity syndrome (CAIS) or MA enrolled in 1 of 3 Kaiser Permanente health-care systems, January 1, 1988–January 31, 2017
- Exposure
- Women with CAIS or MA vs matched male and female referents without disorders/differences of sex development (DSD)
- Outcome
- Prevalence of psychiatric diagnoses (mental health diagnoses and use of psychiatric medications)
Methodological details3 integrated health systems, age-, race/ethnicity- and health system-matched referents
- 3 integrated health systems
- Age-, race/ethnicity- and health system-matched referents
Main finding
As reported in the abstract
Anxiety and depressive disorders
- Prevalence in CAIS and MA approximately twice as high as in male referents
- Differences vs female referents less evident
Observational data: associations, not effects.
Further findings
Bipolar disorder, MA subgroup with uterine agenesis
- Higher prevalence than either reference group, with wide CIs
Psychiatric medication fills
- More frequent in CAIS and MA vs male but not female referents
Original publication
Psychiatric Comorbidities in Women With Complete Androgen Insensitivity Syndrome or Müllerian Duct Aplasia/Agenesis. J Clin Endocrinol Metab. Published 11 October 2024. doi:10.
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