A prospective observational study to evaluate a possible relationship between vitamin K antagonist therapy and risk of peripheral arterial disease in patients with type 2 diabetes
Main finding · PADResult — go to the resultMultivariable adjusted hazard ratio 1.42 95% CI 0.88–2.31Authors' conclusion
In this prospective study, we did not observe any excess risk of PAD requiring lower-limb revascularization in people with type 2 diabetes using VKAs. However, our data suggest a high risk of LLA in VKA users. Further studies are required to confirm this observation.
Study context
- Population
- Patients with T2D in the French SURDIAGENE cohort, prospective follow-up 2002–2015
- Participants
- 1,468 patients
- Exposure
- VKA use vs no VKA use
- Outcome
- First occurrence of PAD, a composite of lower-limb amputation (LLA) or lower-limb revascularization
- Follow-up
- 7-year median
Methodological detailsprospective follow-up
- Prospective follow-up
Main finding
PAD
Multivariable adjusted hazard ratio
1.42
95% CI 0.88–2.31
VKA usersvs Non-users
multivariable aHR 1.42 (95% CI 0.88–2.31)
As reported in the abstract
- Peripheral arterial disease (PAD) occurred in the 1468 participants
- 147 (10%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Multivariable aHR (95% CI) | |
|---|---|---|
| Lower-limb amputation (LLA)Significantly increased risk | 1.90 (1.04–3.47) | |
| Lower-limb revascularizationNot significantly associated | 1.08 (0.59–1.97) | |
| 0.20.5125Multivariable adjusted hazard ratio (log scale) |
- Lower-limb amputation (LLA) — LLA occurred in participants
- 82 (6%)
- Lower-limb revascularization — Lower-limb revascularization occurred in participants
- 105 (7%)
Original publication
A prospective observational study to evaluate a possible relationship between vitamin K antagonist therapy and risk of peripheral arterial disease in patients with type 2 diabetes. Diabetes Obes Metab. Published 15 May 2024. doi:10.
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