Prospective cohort study of cancer incidence and related factors among patients with type 2 diabetes in Japan
Authors' conclusion
Sex, age, abdominal obesity, hypertension, and dyslipidemia may have significant influence cancer risk in Japanese patients with type 2 diabetes.
Study context
- Population
- Outpatients receiving treatment for T2D enrolled in the Nishinomiya Study, Japan
- Participants
- 5,210 outpatients
- Outcome
- Association of baseline clinical characteristics with cancer incidence
- Follow-up
- Mean 4.8 years
Main finding
As reported in the abstract
- Newly diagnosed with cancer
- 411 participants
- Cancer incidence significantly higher in men than in women (Kaplan-Meier)
- p < 0.0001
- Cancer incidence significantly higher with vs without hypertension (Kaplan-Meier)
- p < 0.0001
- Cancer incidence significantly lower with vs without dyslipidemia (Kaplan-Meier)
- p < 0.0001
- Predictor (Cox): higher age
- HR 1.04
- Predictor (Cox): male sex
- HR 1.58
- Predictor (Cox): greater waist circumference
- HR 1.02
- Predictor (Cox): hypertension
- HR 1.40
- Predictor (Cox): absence of dyslipidemia
- HR 0.75
Observational data: associations, not effects.
Original publication
Prospective cohort study of cancer incidence and related factors among patients with type 2 diabetes in Japan. Diabetes Res Clin Pract. Published 17 July 2026. doi:10.
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