Prospective Association Between Weight Variability and Subsequent Long‐Term Weight Loss in the CALERIE Study
Authors' conclusion
Short-term WV predicted lower subsequent weight loss in adults without obesity.
Study context
- Population
- Adults without obesity following a 25% caloric restriction diet over 2 years in the CALERIE study
- Participants
- 143 adults
- Primary endpoint
- Subsequent weight loss (weight at month 3 minus later weights) predicted by short-term WV (root-mean-squared-error of weights over first 12 weeks), adjusted for baseline BMI, 12-week weight change and demographics
- Follow-up
- 6, 12, 18 and 24 months relative to month 3
Methodological detailsprospective, multilevel models
- Prospective
- Multilevel models
Primary result
As reported in the abstract
Association of higher WV with subsequent weight loss · 6 months
- Higher weight variability (WV) associated with less subsequent weight loss: B
- −0.38 [−0.63, −0.13] (95% CI)
- Standardised β
- −0.16
- P
- p = 0.003
Further findings
- Interaction between time and WV not significant; association suggested to extend through year 1
Original publication
Prospective Association Between Weight Variability and Subsequent Long‐Term Weight Loss in the CALERIE Study. Obesity (Silver Spring). Published 18 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →