Short‐Term Versus Long‐Term Efficacy of Endoscopic Sleeve Gastroplasty in 8880 Obese Patients: A Systematic Review and Meta‐Analysis
Authors' conclusion
ESG is associated with clinically meaningful weight loss maintained beyond 6 months with modest attenuation over longer follow-up, alongside favourable metabolic remission rates and low reported weight regain.
Study context
- Population
- Patients with obesity undergoing endoscopic sleeve gastroplasty (ESG); peer-reviewed studies reporting ESG outcomes
- Participants
- 8,880 patients33 studies
- Comparison
- Short-term vs long-term follow-up after ESG
- Outcome
- %TBWL, %EBWL and BMI reduction, stratified by follow-up (≤ 6 months vs. ≥ 1 year)
Methodological detailsrandom-effects models, GRADE assessment, sensitivity analyses, meta-regression for baseline BMI, 31 cohorts, 2 RCTs
- Random-effects models
- GRADE assessment
- Sensitivity analyses
- Meta-regression for baseline BMI
- 31 cohorts, 2 RCTs
Pooled result
As reported in the abstract
%TBWL
%TBWL at 1 month
8.66%
%TBWL at 6 months
16.13%
%TBWL at 1 year
17.88%
%TBWL at 3 years
15.67%
Further pooled results
Metabolic remission rates
- T2D remission
- 62%
- Hypertension remission
- 43%
- Dyslipidaemia remission
- 43%
Weight regain
- Weight regain
- 6%
Baseline BMI meta-regression
- Baseline BMI predicted higher %TBWL but lower %EBWL
Original publication
Short‐Term Versus Long‐Term Efficacy of Endoscopic Sleeve Gastroplasty in 8880 Obese Patients: A Systematic Review and Meta‐Analysis. Diabetes Obes Metab. Published 18 June 2026. doi:10.
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