Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes
Authors' conclusion
The prevalence of CSVD doubled over a 7.5-year period in middle-aged individuals with type 1 diabetes.
Study context
- Population
- Neurologically asymptomatic middle-aged individuals with T1D
- Participants
- 172 individuals
- Exposure
- Baseline vs 7.5-year follow-up
- Outcome
- Progression of cerebral small vessel disease (CSVD) on brain MRI
- Follow-up
- 7.5 years
Methodological detailsfollow-up brain MRI after 7.5 years
- Follow-up brain MRI after 7.5 years
Main finding
As reported in the abstract
Proportion with CSVD
P < 0.001
Observational data: associations, not effects.
Further findings
Proportion with cerebral microbleeds (CMBs) · 7.5 years
P < 0.001
Proportion with white matter hyperintensities (WMHs) · 7.5 years
P < 0.001
Baseline predictors of change
- Increase in cerebral microbleeds (CMBs) associated with baseline systolic blood pressure, HbA1c and preexisting CMBs
- Increases in cerebral small vessel disease (CSVD) and white matter hyperintensities (WMHs) associated only with age
Original publication
Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes. Diabetes Care. Published 17 March 2025. doi:10.
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