Prognostic implication of stress hyperglycemia in patients with acute coronary syndrome undergoing percutaneous coronary intervention
Authors' conclusion
In ACS patients undergoing PCI, low and high glucose/GA ratio values were associated with an increased all-cause and cardiovascular mortality, especially in those with diabetes mellitus.
Study context
- Population
- Acute coronary syndrome (ACS) patients who underwent percutaneous coronary intervention (PCI), CBDBANK, January 2013 to January 2021; stress hyperglycemia defined by glucose/glucose/glycated albumin (GA) ratio (admission fasting plasma glucose divided by GA)
- Participants
- 5,190 patients
- Exposure
- Glucose/GA ratio quartiles
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 4.0 years
Main finding
As reported in the abstract
All-cause mortality
Each group vs Q2Hazard ratio (95% CI)
Q1
1.43(1.01–2.03)
Q4
1.51(1.03–2.21)
- All-cause deaths, whole cohort
- 313 (6.0%)
- U-shaped association between glucose/GA ratio and all-cause mortality after full adjustment (restricted cubic splines)
- P nonlinear = 0.008
Observational data: associations, not effects.
Further findings
Cardiovascular mortality · median follow-up 4.0 years
- Cardiovascular-associated deaths, whole cohort
- 177 (3.4%)
- Similar results observed for cardiovascular mortality
Subgroups by diabetes status
- U-shaped relationship only significant in patients with DM
Original publication
Prognostic implication of stress hyperglycemia in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Cardiovasc Diabetol. Published 21 March 2023. doi:10.
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