Pro-inflammatory immune microenvironment and Thrombospondin-1-positive monocytes as drivers of osteoclastogenesis in postmenopausal osteoporosis
Authors' conclusion
This study provides a detailed characterization of bone marrow cell heterogeneity in postmenopausal women, offering insights into potential therapeutic strategies targeting PMOP.
Study context
- Population
- Bone marrow cells from postmenopausal osteoporosis (PMOP) patients and controls (93,867 cells)93,867 cells
- Participants
- 10 vs 10
- Comparison
- PMOP patients vs controls
- PMOPn = 10
- Controlsn = 10reference
- Outcome
- Bone marrow cellular landscape and osteoclastogenic pathways
Methodological detailssingle-cell RNA sequencing, histological validation, in vitro modulation, mouse models
- Single-cell RNA sequencing
- Histological validation
- In vitro modulation
- Mouse models
Main finding
As reported in the abstract
- Monocyte subsets with osteoclastogenic potential (THBS1+ with CCL20+, or LRP1+, or C1QA+), associated with NOD-like receptor pathway activation
- 3
Original publication
Pro-inflammatory immune microenvironment and Thrombospondin-1-positive monocytes as drivers of osteoclastogenesis in postmenopausal osteoporosis. J Bone Miner Res. Published 14 June 2025. doi:10.
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