Complement factor H (CFH), an immune factor enhances osteoblast differentiation and correlates with bone density
Authors' conclusion
These findings establish CFH as a key regulator of osteogenesis and bone homeostasis, with potential implications for bone-related disorders.
Study context
- Population
- Human bone marrow skeletal stem cells (hBMSCs), CFH-deficient (CFH-/-) mice and patients (bone marrow plasma and plasma CFH levels)
- Comparison
- CFH deficiency vs CFH overexpression/supplementation and wild-type
- Outcome
- Effects of CFH on OB differentiation and bone homeostasis
Methodological detailsin vitro hBMSC experiments, CFH-deficient mice, clinical association analysis
- In vitro hBMSC experiments
- CFH-deficient mice
- Clinical association analysis
Main finding
As reported in the abstract
- CFH-deficient hBMSCs exhibited impaired osteoblast (OB) differentiation; CFH overexpression or supplementation enhanced OB differentiation
- CFH-/- mice: reduced trabecular and cortical bone mass, decreased bone formation, diminished bone strength
- CFH-/- mBMSCs: reduced osteogenesis, enhanced osteoclast differentiation; lower serum P1NP, elevated TRAPc and CTX-1
- CFH-/- mice: delayed fracture healing and accelerated bone loss after ovariectomy or high-fat diet
- Bone marrow plasma CFH negatively correlated with fracture risk in patients
- Plasma CFH positively associated with bone mineral density (BMD) and significantly reduced in osteoporosis
Original publication
Complement factor H (CFH), an immune factor enhances osteoblast differentiation and correlates with bone density. J Bone Miner Res. Published 16 June 2026. doi:10.
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