Primary Hyperparathyroidism Associated With Elevated Coronary Artery Calcium Scores and Increased Cardiovascular Risk
Main finding · CAC scores ≥100Result — go to the resultOdds ratio 1.5 95% CI 1.1–2.7Authors' conclusion
Patients with PHPT had higher proportions of CAC scores ≥100, suggesting greater cardiovascular event risk. Men with PHPT had significantly higher CAC scores compared to women, and untreated parathyroid disease was associated with moderate-to-severe coronary calcific burden. Therefore, routine screening may be considered in PHPT populations to evaluate for cardiovascular risk.
Study context
- Population
- Patients who underwent coronary artery calcium (CAC) scoring (2015–2024) with concurrent serum calcium and PTH within 1 year of CAC testing
- Participants
- 415 patients
- Exposure
- Primary hyperparathyroidism (PHPT) vs non-PHPT
- PHPTn = 75
- non-PHPTn = 340reference
- Outcome
- CAC score ≥100 (high cardiovascular risk) vs 0-99 (low-intermediate)
Main finding
CAC scores ≥100
Odds ratio
1.5
95% CI 1.1–2.7
P = 0.03
By group
PHPT
67
%
non-PHPT
50%
PHPTvs non-PHPT
OR 1.5 (95% CI 1.1–2.7); P = 0.03
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Male PHPT | Female PHPT | P value |
|---|---|---|---|
| CAC score in PHPT, by sex | 495 (IQR 51–634) | 6 (IQR 0–190) | P < 0.01 |
Moderate-to-severe coronary calcific burden with longer untreated PHPT duration
- OR (95% CI 1.1-1.3), P < .01
- 1.2
Original publication
Primary Hyperparathyroidism Associated With Elevated Coronary Artery Calcium Scores and Increased Cardiovascular Risk. Endocr Pract. Published 17 December 2025. doi:10.
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