Prevalence and Predictive Factors for Celiac Disease in Children With Type 1 Diabetes: Whom and When to Screen? A Nationwide Longitudinal Cohort Study of Swedish Children
Authors' conclusion
Age at and time after diabetes diagnosis should be considered in screening guidelines for CD in children with T1D.
Study context
- Population
- Children and adolescents with T1D from the Better Diabetes Diagnosis study in Sweden
- Participants
- 5,295 children
- Outcome
- Prevalence of biopsy-proven celiac disease (CD) and predictive factors (sex, age at T1D diagnosis, HLA, diabetes autoantibodies) for CD after T1D
Main finding
As reported in the abstract
Prevalence of biopsy-proven CD
Prevalence of biopsy-proven celiac disease (CD)
9.8%
Of those with CD, diagnosed before or at T1D onset
58.2%
Diagnosed with CD within 5 years after T1D diagnosis
95.9%
Observational data: associations, not effects.
Further findings
Predictive factors for CD after T1D
- Younger age at T1D diagnosis and DQ2 homozygosity increased the risk of CD after T1D
- Neither sex nor diabetes-related autoantibodies were associated with the risk
Original publication
Prevalence and Predictive Factors for Celiac Disease in Children With Type 1 Diabetes: Whom and When to Screen? A Nationwide Longitudinal Cohort Study of Swedish Children. Diabetes Care. Published 16 February 2024. doi:10.
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