Clinical Characteristics in Swedish Children With and Without Autoantibodies at the Time of Type 1 Diabetes Diagnosis
Authors' conclusion
We identified differences in clinical characteristics when comparing children with and without autoantibodies at type 1 diabetes diagnosis, highlighting potential heterogeneity in the disease's pathogenesis across subgroups.
Study context
- Population
- Children (<18 years) at T1D diagnosis, Sweden's national Better Diabetes Diagnosis study
- Participants
- 2,753 children
- Exposure
- Autoantibody-negative vs autoantibody-positive children at T1D diagnosis
- Autoantibody-negativen = 169
- Outcome
- Autoantibody-negative at T1D diagnosis
- Follow-up
- Diagnosis
Methodological detailsnational, Better Diabetes Diagnosis study
- National
- Better Diabetes Diagnosis study
Main finding
As reported in the abstract
Autoantibody-negative
6.1%
169
Observational data: associations, not effects.
Further findings
| Outcome | Autoantibody-negative | P value |
|---|---|---|
| Boys · diagnosisAutoantibody-negative vs Autoantibody-positive | 66% | P = 0.009 |
| HbA1c · diagnosisAutoantibody-negative vs Autoantibody-positive · higher without autoantibodies | 11.3 % | P = 0.003 |
| Mmol/mol | 100 | |
| DKA at presentation · diagnosisAutoantibody-negative vs Autoantibody-positive · less likely without autoantibodies | 9% | P = 0.039 |
| Parental history of T2DAutoantibody-negative vs Autoantibody-positive · more likely without autoantibodies | 8% | P < 0.001 |
- Boys: Autoantibody-positive 56%
- HbA1c: Autoantibody-positive 10.8 % · mmol/mol 94
- Diabetic ketoacidosis (DKA) at presentation: Autoantibody-positive 15%
- Parental history of T2D: Autoantibody-positive 2%
Age at diagnosis, C-peptide, BMI-SDS, HLA genotype
- No differences between children with and without autoantibodies
Original publication
Clinical Characteristics in Swedish Children With and Without Autoantibodies at the Time of Type 1 Diabetes Diagnosis. Diabetes Care. Published 15 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →