Prevalence, incidence, and 6-years stability of metabolically unhealthy normal weight́s phenotype in u.s. hispanic/latino adults
Authors' conclusion
MUNW predicts progression to MUO and is associated with worsening cardiometabolic profiles.
Study context
- Population
- Normal-weight adults (BMI ≥ 18.5, <25 kg/m²; 18–74 years) from the Hispanic Community Health Study/Study of Latinos, free of cardiometabolic disease at baseline
- Participants
- 2,357 adults
- Outcome
- Prevalent and incident MUNW (normal weight with ≥ 1 cardiometabolic risk factor, harmonized metabolic syndrome criteria) and its stability
- Follow-up
- 6 years
Methodological details6-year follow-up, multivariable models
- 6-year follow-up
- Multivariable models
Main finding
As reported in the abstract
MUNW prevalence at baseline
43.9%
Initially metabolically healthy normal-weight participants who developed MUNW at follow-up (main predictor: age)
22.9%
Remained MUNW after 6 years
44.2 %
Observational data: associations, not effects.
Further findings
Progression to metabolically unhealthy overweight/obesity (MUO) by baseline MUNW · 6 years
- Risk ratios, adjusted for baseline BMI and waist circumference (WC) (p < 0.0001)
- 1.85-2.37
Cardiometabolic risk factor (CMRF) accumulation in those who remained MUNW · 6 years
- Those remaining MUNW accumulated more CMRFs (p < 0.05)
Original publication
Prevalence, incidence, and 6-years stability of metabolically unhealthy normal weight́s phenotype in u.s. hispanic/latino adults. Diabetes Res Clin Pract. Published 2 July 2026. doi:10.
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