Target tissue insulin resistance in early and late onset of overweight or obesity
Authors' conclusion
When current BMI or age is considered, there is no difference between early or late onset of overweight/obesity for the level of insulin resistance in the different target tissues of the hormone.
Study context
- Population
- Adults with information on body mass index (BMI) at 18 years of age
- Participants
- 339 adults
- Exposure
- Early vs late onset of overweight/obesity vs never overweight
- Outcome
- Target tissue insulin action: HOMA-IR (liver), hyperinsulinemic euglycemic clamp (skeletal muscle), Adipo-IR (adipose tissue), insulin action on lipogenesis (fat cells)
Main finding
As reported in the abstract
Insulin resistance, EO vs LO
- After correction for current BMI or age, no significant differences between EO and LO for any measure of insulin action
- p ≥ 0.08
Observational data: associations, not effects.
Further findings
BMI and age at examination, EO vs LO
- EO had 5 kg/m² higher BMI and was 10 years younger than LO (p < 0.0001)
Correlation of BMI with insulin resistance measures, all subjects
- Current BMI correlated with insulin resistance measures
- P < 0.0001
- BMI at 18 years did not correlate with insulin resistance measures
- P ≥ 0.13
Original publication
Target tissue insulin resistance in early and late onset of overweight or obesity. Int J Obes (Lond). Published 2 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →