Prevalence and Clinical Predictors of Subacute Thyroiditis in Patients with thyrotoxicosis: A Prospective Study
Authors' conclusion
SAT represents a substantial, clinically relevant subset of thyrotoxicosis. Inflammatory clinical features and CRP positivity, and low 24-hour RAIU were prominent findings associated with SAT, whereas demographic characteristics and the magnitude of total T3 and total T4 elevation showed limited discriminatory value.
Study context
- Population
- Patients with biochemically confirmed thyrotoxicosispatients with biochemically confirmed thyrotoxicosis evaluated
- Participants
- 300 patients
- Exposure
- Subacute thyroiditis (SAT) vs non-SAT groups
- Outcome
- Etiology of thyrotoxicosis
Main finding
As reported in the abstract
Graves' disease (most common)
61%
SAT
25.3%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Thyroid tenderness, anterior neck pain, sore throat and recent URIMore frequent in SAT group | P ≤ 0.023 |
| Proptosis and tremorNot observed in SAT group | P = 0.001 |
| Median TSHHigher in SAT | P˂ 0.001 |
| ESR and CRP positivity | P < 0.001 |
- Thyroid nodules — Thyroid nodules (less frequent) · less frequent in SAT
- 9.2% · P = 0.009
- ESR and CRP positivity: ESR significantly elevated and CRP positivity substantially more frequent in SAT
Age, sex and seasonal distribution
- Similar between groups
Likelihood ratios of clinical features for SAT
- Thyroid tenderness LR+
- 115.5
- Recent URI LR+
- 503.5
- Most discriminating clinical features for SAT
24-hour radioactive iodine uptake (RAIU)
- Low 24-hour RAIU observed in all patients with SAT
Original publication
Prevalence and Clinical Predictors of Subacute Thyroiditis in Patients with thyrotoxicosis: A Prospective Study. Endocr Pract. Published 6 November 2026. doi:10.
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