High-dose intravenous methylprednisolone is effective in subacute thyroiditis unresponsive to oral steroids
Authors' conclusion
IVMP therapy resulted in a rapid clinical and ultrasonographic improvement in most patients with relapsing SAT unresponsive to oral steroids. This response allowed for a shorter treatment duration, with good tolerability, minimal adverse events, and a low incidence of hypothyroidism during follow-up.
Study context
- Population
- Patients with subacute thyroiditis (SAT) relapsing or refractory to oral prednisone, 2014–2024
- Participants
- 14 patients
- Outcome
- Response at end of treatment
- Follow-up
- End of treatment
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Complete clinical, ultrasonographic and biochemical response
12
86%
Immediate resolution of neck pain and thyrotoxicosis
13
93%
No improvement at end of intravenous methylprednisolone (IVMP); delayed remission with persistent hypothyroidism
1
Further findings
Treatment duration
- Median (IQR) duration of treatment
- 26 days (21-38)
Immediate resolution of neck pain and thyrotoxicosis · end of treatment
- Immediate resolution of neck pain and thyrotoxicosis
- 13 (93%)
Non-response and hypothyroidism · end of IVMP protocol and follow-up
- Did not improve at end of IVMP protocol; delayed remission with persistent hypothyroidism
- 1 patient
Safety
Mild grade 1 and 2 AEs (hyperglycemia, arterial hypertension, neutrophilia)
- Patients with AEs
- 8 out of 14
Original publication
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