Pregnancy, delivery and neonatal outcomes among women with hypoparathyroidism—A population‐based study
Main finding · Preterm birth (<37 weeks)Result — go to the resultAdjusted odds ratio 2.49 95% CI 1.74–3.54Authors' conclusion
This is the largest study of chronic hypoparathyroidism in pregnancy to date. We found significant increases in the rates of preterm birth, blood transfusions and congenital anomalies in chronic hypoparathyroidism. Our findings highlight the importance of identifying chronic hypoparathyroidism as a risk factor for pregnancy and neonatal complications, although it remains unknown if maintaining calcium in the target range will mitigate these risks.
Study context
- Population
- Pregnancies in the HCUP Nationwide Inpatient Sample, 2004–2014pregnancies
- Participants
- 204 vs 9,096,584
- Exposure
- Chronic hypoparathyroidism vs no chronic hypoparathyroidism
- Hypoparathyroidismn = 204
- Without hypoparathyroidismn = 9,096,584reference
- Outcome
- Preterm birth (<37 weeks)
Methodological detailsHealthcare Cost and Utilization Project Nationwide Inpatient Sample (HCUP-NIS) database, multivariate logistic regression
- HCUP-NIS database
- Multivariate logistic regression
Main finding
As reported in the abstract
Adjusted odds ratio
2.49
95% CI 1.74–3.54
P < 0.0001
By group
Observational data: associations, not effects.
Further findings
| Outcome | Hypoparathyroidism | Without hypoparathyroidism | aOR (95% CI) | P value | |
|---|---|---|---|---|---|
| Congenital anomalies in neonates | 4.4% | 0.4% | 6.50 (3.31–12.75) | P < 0.0001 | |
| 0.050.21520Adjusted odds ratio (log scale) |
Small-for-gestational-age neonates and intrauterine foetal death
- Comparable rates of small-for-gestational-age neonates and intrauterine foetal death
Safety
| Outcome | Hypoparathyroidism | Without hypoparathyroidism | aOR (95% CI) | P value | |
|---|---|---|---|---|---|
| Blood transfusions | 4.9% | 1.0% | 4.07 (2.15–7.73) | P < −0.0001 | |
| 0.10.31310Adjusted odds ratio (log scale) |
Original publication
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