Predicting Tumor Volume in Primary Hyperparathyroidism From Preoperative Clinical Data
Authors' conclusion
Preoperative serum intact PTH value is associated with tumor volume of the lesion responsible for PHPT. A rough estimation of the tumor size would provide responsible physicians with opportunities to add further imaging tests or plan appropriate surgical strategies.
Study context
- Population
- Patients with surgically treated primary hyperparathyroidism (PHPT) who underwent initial surgery in one department, January 2000–December 2021
- Outcome
- Volume of parathyroid gland removed; associations with preoperative clinical data by multivariable analysis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Predictors of tumor volume (ln-volume)
- Correlation of tumor volume with preoperative intact parathyroid hormone (PTH) (Spearman's r)
- 0.503
- Correlation of tumor volume with preoperative calcium (Spearman's r)
- 0.338
- Male sex: standardized regression coefficient
- 0.213 (0.103-0.323) (95% CI)
- ln-PTH: standardized regression coefficient
- 0.5018 (0.4442-0559) (95% CI)
- Calcium: standardized regression coefficient
- 0.322 (0.0339-0.149) (95% CI)
- Adjusted R2 of model
- 0.320
Observational data: associations, not effects.
Original publication
Predicting Tumor Volume in Primary Hyperparathyroidism From Preoperative Clinical Data. J Clin Endocrinol Metab. Published 25 March 2024. doi:10.
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