Prediabetes Phenotypes and All-Cause or Cardiovascular Mortality: Evidence From a Population-Based Study
Authors' conclusion
A higher number of diagnostic criteria for prediabetes was associated with increased all-cause and CVD mortality.
Study context
- Population
- Individuals with prediabetes with fasting plasma glucose (FPG), HbA1c, 2h PG and mortality data, NHANES 2005–2016
- Participants
- 4,511 individuals
- Exposure
- Two or three prediabetes criteria vs one criterion
- One criterionn = 2,609reference
- Two criterian = 1,420
- Three criterian = 482
- Outcome
- All-cause and CVD mortality
- Follow-up
- Median 100 months
Methodological detailsNHANES 2005-2016
- NHANES 2005-2016
Main finding
As reported in the abstract
All-cause mortality
Each group vs one criterionMultivariable-adjusted HR (95% CI)P value
Two criteria
1.341(1.042–1.727)
P = 0.006for trendThree criteria
1.369(1.027–1.824)
P = 0.006for trend- Total deaths
- 534
Observational data: associations, not effects.
Further findings
| Outcome | Multivariable-adjusted HR (95% CI) | P value | |
|---|---|---|---|
| CVD mortality · median follow-up 100 monthsTwo criteriavs One criterion | 1.836 (1.228–2.744) | P for trend = 0.002 | |
| CVD mortality · median follow-up 100 monthsThree criteriavs One criterion | 2.037 (1.092–3.801) | P for trend = 0.002 | |
| 0.20.5125Multivariable-adjusted HR (log scale) |
- Cardiovascular disease (CVD) mortality — CVD-related deaths
- 180
CVD mortality by subgroup
- Association between number of criteria and CVD mortality observed only in men
Original publication
Prediabetes Phenotypes and All-Cause or Cardiovascular Mortality: Evidence From a Population-Based Study. Endocr Pract. Published 19 January 2025. doi:10.
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