Prediabetes, intervening diabetes and subsequent risk of dementia: the Atherosclerosis Risk in Communities (ARIC) study
Authors' conclusion
Prediabetes is associated with dementia risk but this risk is explained by the subsequent development of diabetes. Earlier age of onset of diabetes substantially increases dementia risk. Preventing or delaying progression of prediabetes to diabetes will reduce dementia burden.
Study context
- Population
- ARIC participants without diabetes at baseline (1990–1992), aged 46–70 yearswithout diabetes at baseline
- Participants
- 11,656 participants
- Exposure
- Prediabetes vs no prediabetes, before and after accounting for incident diabetes
- Prediabetesn = 2,330
- Outcome
- Incident dementia
Methodological detailscommunity-based, adjudicated dementia ascertainment
- Community-based
- Adjudicated dementia ascertainment
Main finding
As reported in the abstract
Dementia risk
Prediabetes vs No prediabetesHazard ratio (95% CI)
Before accounting for incident diabetes
1.12(1.01–1.24)
After accounting for incident diabetes; non-significant
1.05(0.94–1.16)
Observational data: associations, not effects.
Further findings
Dementia risk by age at diabetes onset
- Diabetes onset <60 years, HR
- 2.92 (2.06, 4.14) (95% CI)
- Diabetes onset 60-69 years, HR
- 1.73 (1.47, 2.04) (95% CI)
- Diabetes onset 70-79 years, HR
- 1.23 (1.08, 1.40) (95% CI)
- Earlier onset had the strongest association
Original publication
Prediabetes, intervening diabetes and subsequent risk of dementia: the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia. Published 24 May 2023. doi:10.
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