Age of Diabetes Diagnosis and Lifetime Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study
Authors' conclusion
Preventing or delaying diabetes may be an important approach for reducing dementia risk throughout the life course.
Study context
- Population
- ARIC Study participants free from dementia at age 60 years
- Participants
- 13,087 participants
- Exposure
- Middle age-onset diabetes vs older-onset diabetes vs no diabetes
- Outcome
- Lifetime risk of dementia (incident dementia ascertained via adjudication and active surveillance)
- Follow-up
- Median 24.1 (percentile 25-percentile 75, 17.4-28.3) years
Methodological detailscompeting risk of mortality accounted for, cumulative incidence function estimator, restricted mean survival time
- Competing risk of mortality accounted for
- Cumulative incidence function estimator
- Restricted mean survival time
Main finding
As reported in the abstract
Lifetime risk of dementia
Observational data: associations, not effects.
Further findings
| Outcome | Middle age-onset diabetes | No diabetes |
|---|---|---|
| Cumulative incidence of dementia by age 80 years | 16.1% | 9.4% |
Timing of dementia onset
- Middle age-onset diabetes developed dementia earlier than no diabetes
- 4 years
- Middle age-onset diabetes developed dementia earlier than older-onset diabetes
- 1 year
Events during follow-up (all participants)
- Individuals with dementia
- 2,982
- Deaths without dementia
- 4,662
Original publication
Age of Diabetes Diagnosis and Lifetime Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care. Published 27 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →