Prediabetes and the risk of type 2 diabetes: Investigating the roles of depressive and anxiety symptoms in the Lifelines cohort study
Authors' conclusion
Individuals with elevated depressive, and to some extent anxiety, symptoms in combination with prediabetes may represent a high-risk subgroup for type 2 diabetes.
Study context
- Population
- Adults aged ≥40 years without diabetes at baseline, Lifelines Cohort Study (58% female; mean age 51.4 years); prediabetes by HbA1c at baseline (2007–2013), symptoms screened by Mini-International Neuropsychiatric Interview
- Participants
- 72,428 adults
- Exposure
- Prediabetes with or without elevated depressive/anxiety symptoms vs neither
- Outcome
- Incident T2D (HbA1c and self-reported diagnosis)
- Follow-up
- 2014-2017
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Incident diabetes
Each group vs referenceOdds ratio (95% CI)P value
Prediabetes alone
5.94(5.10–6.90)
P < 0.001Prediabetes + depressive symptomshighest likelihood of developing diabetes
8.29(5.58–12.32)
P < 0.001Prediabetes + anxiety symptoms
6.57(4.62–9.33)
P < 0.001Prediabetes aloneanxiety analysis
6.09(5.23–7.11)
P < 0.001- Developed diabetes
- 1300 (1.8%)
Observational data: associations, not effects.
Original publication
Prediabetes and the risk of type 2 diabetes: Investigating the roles of depressive and anxiety symptoms in the Lifelines cohort study. Diabet Med. Published 17 February 2023. doi:10.
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