Associations of Insomnia With Insulin Resistance Traits: A Cross-sectional and Mendelian Randomization Study
Authors' conclusion
This study provides robust evidence supporting that more frequent insomnia symptoms are associated with IR and its related traits across different angles. These findings indicate that insomnia symptoms can be served as a promising target to improve IR and prevent subsequent T2D.
Study context
- Population
- UK Biobank participants
- Exposure
- More frequent vs less frequent insomnia symptoms
- Outcome
- IR (triglyceride-glucose index and TG/HDL-C ratio) and related traits (glucose level, TG, HDL-C)
Methodological detailsmultivariable regression, 1-sample Mendelian randomization, 2-sample Mendelian randomization, 2-step MR mediation analysis, Bonferroni adjustment
- Multivariable regression
- 1-sample Mendelian randomization
- 2-sample Mendelian randomization
- 2-step MR mediation analysis
- Bonferroni adjustment
Main finding
As reported in the abstract
Associations of more frequent insomnia symptoms with IR traits
- Triglyceride-glucose index, multivariable regression (MVR) β
- 0.024, P < 2.00E-16
- Triglyceride-glucose index, 1SMR β
- 0.343, P < 2.00E-16
- TG/HDL-C ratio, MVR β
- 0.016, P = 1.75E-13
- TG/HDL-C ratio, 1SMR β
- 0.445, P < 2.00E-16
- TG level, MVR β
- 0.019 log mg/dL, P < 2.00E-16
- TG level, 1SMR β
- 0.289 log mg/dL, P < 2.00E-16
Observational data: associations, not effects.
Further findings
2SMR validation
- Similar evidence obtained using 2SMR
Proportion of insomnia–T2D association mediated by insulin resistance (IR)
- Mediated by IR
- 25.21%
- 2-step MR design
Original publication
Associations of Insomnia With Insulin Resistance Traits: A Cross-sectional and Mendelian Randomization Study. J Clin Endocrinol Metab. Published 16 February 2023. doi:10.
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