Empagliflozin and Renal Sodium-Hydrogen Exchange in Healthy Subjects
Authors' conclusion
In healthy young volunteers, empagliflozin acutely increases urinary pH while inducing a substrate shift toward lipid utilization and ketogenesis, without significant changes in renal NHE3 protein expression.
Study context
- Population
- Healthy male volunteers
- Participants
- 20 vs 6
- Comparison
- Before vs after empagliflozin 2 × 25 mg
- Empagliflozinn = 20
- Time-controln = 6reference
- Outcome
- Urine pH
- Follow-up
- 6 hours
Methodological detailsproof-of-concept, standardized hydration scheme, time-control study
- Proof-of-concept
- Standardized hydration scheme
- Time-control study
Main finding
As reported in the abstract
Urine pH increased after empagliflozin (before → after; mean ± SD as printed)
5.81 ± 0.5 to 6.16 ± 0.6
P = .008
Further findings
Time-control study
- Neither urine pH nor plasma and urinary parameters changed
Original publication
Empagliflozin and Renal Sodium-Hydrogen Exchange in Healthy Subjects. J Clin Endocrinol Metab. Published 16 February 2023. doi:10.
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