Precision nutrition in weight loss and neuroendocrine control of people with obesity: The study protocol of a factorial randomised controlled trial ( GenON Programme)
Study context
- Population
- Adults with overweight and obesity classified as high or low genetic risk for obesity (FTO rs9,939,609 and rs1,121,980; MC4R rs1,782,313; LEP rs7,799,039)planned
- Participants
- 120 adults
- Planned comparison
- Satiety-focused vs standard dietary counselling, in high vs low genetic risk for obesity
Methodological details2 × 2 factorial, 18-week, Assessments at baseline, week 12 and week 18: weight loss, body composition, satiety perception, quality of life, cardiometabolic markers, (epi)genetics, inflammation, neuroendocrine regulation, metagenomics
- 2 × 2 factorial
- 18-week
- Assessments at baseline, week 12 and week 18: weight loss, body composition, satiety perception, quality of life, cardiometabolic markers, (epi)genetics, inflammation, neuroendocrine regulation, metagenomics
No results yet. This paper sets out the design of a trial; its results are to come.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Precision nutrition in weight loss and neuroendocrine control of people with obesity: The study protocol of a factorial randomised controlled trial ( GenON Programme). Diabetes Obes Metab. Published 2 January 2026. doi:10.
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