Precision Medicine to Redefine Insulin Secretion and Monogenic Diabetes-Randomized Controlled Trial (PRISM-RCT) in Chinese patients with young-onset diabetes: design, methods and baseline characteristics
Authors' conclusion
Young-onset diabetes is characterized by complex etiologies with comorbidities including mental illness and lifecourse events.
Study context
- Population
- Chinese patients with T2D diagnosed at ≤40 years of age and aged ≤50 yearsenrolled 2020–2021
- Participants
- 884 patients
- Comparison
- JADE-PRISM vs usual care
- JADE-PRISMn = 441
- Joint Asia Diabetes Evaluation (JADE)-onlyn = 443reference
- Primary endpoint
- Incidence of all diabetes-related complications
Methodological details3-year
- 3-year
Primary result
As reported in the abstract
Baseline characteristics
- Men
- 56.6%
- Diabetes duration, median (IQR)
- 7 (3-12) years
- Current/ex-smokers
- 32.5%
- BMI
- 28.40±5.77 kg/m²
- HbA1c
- 7.52%±1.66%
- Insulin-treated
- 27.7%
- Positive family history
- 74.7%
- General obesity
- 51.4%
- Central obesity
- 79.2%
- Hypertension
- 66.7%
- Dyslipidemia
- 76.4%
- Albuminuria
- 35.4%
- eGFR <60 mL/min/1.73 m²
- 4.0%
- Retinopathy
- 13.8%
- Atherosclerotic CVD
- 5.2%
- Cancer
- 3.1%
- Emotional distress
- 26%-38%
- Suboptimal adherence
- 54%
- EuroQol 5-item Quality of Life index
- 0.88 (0.87-0.96)
- Attained ≥3 metabolic targets
- 13.7%
- Low/large birth weight
- 33.4%
- Childhood obesity
- 50.7%
- Mental illness
- 10.3%
- Previous suicide attempts
- 3.6%
- Women: polycystic ovary syndrome
- 17.3%
- Women: insulin treatment during pregnancy
- 44.8%
- Women: adverse pregnancy outcomes
- 17.3%
Secondary outcomes
Biogenetic markers in JADE-PRISM · baseline
- Pathogenic/likely pathogenic variants of monogenic diabetes genes
- 4.5%
- Autoantibodies
- 5%
- Fasting C-peptide <0.2 nmol/L
- 8.4%
Original publication
Precision Medicine to Redefine Insulin Secretion and Monogenic Diabetes-Randomized Controlled Trial (PRISM-RCT) in Chinese patients with young-onset diabetes: design, methods and baseline characteristics. BMJ Open Diabetes Res Care. Published 19 June 2024. doi:10.
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