Potential benefits of hybrid closed‐loop systems for managing moderate‐ to high‐risk individuals with type 1 diabetes during Ramadan fasting
Main finding · Composite endpoint (>15 fasting days, TIR ≥70%, TBR <4%)Result — go to the resultOdds ratio 9.4 95% CI 3.1–28.4Authors' conclusion
For moderate-to-high risk individuals with T1D, HCL substantially improves the safety and feasibility of prolonged daytime fasting during Ramadan, outperforming MDI + CGM in achieving glycaemic and fasting targets. While the results favour HCL, causal inference is still limited, given the lack of randomization and cross-over design. Concurrently, there is a need to update current recommendations for high-risk populations and underscore the central role of advanced diabetes technology in Ramadan.
Study context
- Population
- Adults with T1D at moderate-to-high risk (International Diabetes Federation-Diabetes and Ramadan (IDF-DAR) criteria) who chose to fast in Ramadan 2024
- Participants
- 178 adults
- Exposure
- HCL vs MDI + CGM during Ramadan fasting
- HCLn = 98
- MDI + CGMn = 80reference
- Outcome
- Composite:
- Completing >15 days of fasting and achieving time in range (TIR) ≥70%
- With time below range (TBR) <4%
- Follow-up
- Ramadan 2024
Methodological detailsmulticentre, real-world setting
- Multicentre
- Real-world setting
Main finding
As reported in the abstract
- >15 fasting days
- TIR ≥70%
- TBR <4%
Odds ratio
9.4
95% CI 3.1–28.4
By group
HCL
Half
MDI + CGM
8%
Observational data: associations, not effects.
Further findings
Age at baseline
P = 0.049
- Completing all possible fasting days · more frequent with HCL
- P < 0.05
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →