Glycemic variability and iatrogenic hypoglycemia: how to resolve
Authors' conclusion
As such thresholds are the upper limit or the averaged value of %CV glucose, respectively, in non-diabetic people, the ultimate goal to prevent hypoglycemia in people with type 1 diabetes on intensive insulin therapy should be to achieve a near normal glycemic variability. Achieving such a goal needs further improvements in insulin delivery systems.
Study context
- Population
- People with T1D treated with SAP (Sensor Augmented Pump) or AID38 RCTs
- Primary endpoint
- %CV glucose threshold below which hypoglycaemia risk is minimised or eliminated
Primary result
As reported in the abstract
Mean reduction in %CV glucose (percentage points) associated with a mean decrease in TBR <70 mg/dL of ≈0.50 % (percentage points)
2.0 %
%CV glucose below which hypoglycaemia risk becomes negligible
27 %
%CV glucose below which hypoglycaemia risk is eventually eliminated
19 %
Original publication
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