Postprandial glucose variability and clusters of sex hormones, liver enzymes, and cardiometabolic factors in a South African cohort of African ancestry
Authors' conclusion
We demonstrated that inter-individual differences in PPG responses to an OGTT may be differentially explained by body fat distribution, serum lipids, liver enzymes, and steroid hormones in men and women.
Study context
- Population
- South Africans of African ancestry, men and women, Middle-aged Soweto Cohort
- Participants
- 794 participants
- Exposure
- Men vs Women
- Outcome
- Variance in PPG (integrated area under the glucose curve during oral glucose tolerance test (OGTT)) explained by clusters (principal components (PCs)) of sex hormones, liver enzymes and cardiometabolic factors and by T2D PRS
Methodological detailsprincipal component analysis, stratified by sex, multivariable linear regression
- Principal component analysis
- Stratified by sex
- Multivariable linear regression
Main finding
As reported in the abstract
Variance in PPG explained by PCs
Observational data: associations, not effects.
Original publication
Postprandial glucose variability and clusters of sex hormones, liver enzymes, and cardiometabolic factors in a South African cohort of African ancestry. BMJ Open Diabetes Res Care. Published 7 March 2024. doi:10.
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