Postprandial Glucose Turnover Differs Between Adolescents and Adults With Type 1 Diabetes: Triple Tracer Mixed Meal Study
Authors' conclusion
We report differences in parameters of postprandial glucose turnover and insulin sensitivity between adults and early adolescents with T1D that could, at least in part, be due to the shorter duration of diabetes among T1D-adol. These data support the concept that over time with T1D, endogenous glucose production increases and SI deteriorates.
Study context
- Population
- Early adolescents and adults with T1D, and matched adults without diabetes, at a clinical research unit
- Participants
- 21 / 13 / 14
- Exposure
- Adolescents with T1D vs adults with T1D
- T1D-adoln = 21
- T1D-adultn = 13reference
- NDn = 14
- Outcome
- Postprandial glucose turnover and insulin sensitivity (SI)
Methodological detailsclinical research unit, triple tracer mixed meal, oral glucose models
- Clinical research unit
- Triple tracer mixed meal
- Oral glucose models
Main finding
As reported in the abstract
SI
- Integrated endogenous glucose production and glucose disappearance lower in T1D-adol than T1D-adult and in ND vs T1D-adult; no difference T1D-adol vs ND
- Meal glucose appearance did not differ between groups
- T1D-adol vs ND: P = 0.299
- T1D-adol vs T1D-adult: P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Postprandial glucose excursionsT1D-adol vs T1D-adult · not different | P = 0.111 |
| Insulin excursionsT1D-adol vs T1D-adult · similar | P = 0.600 |
Postprandial glucose excursions
- Higher in T1D-adol and T1D-adult than in ND (P < .01)
Insulin excursions
- Both lower vs ND (P < .05)
Glucagon excursions
- Lower in T1D-adol than in T1D-adult and ND (P < .01)
Original publication
Postprandial Glucose Turnover Differs Between Adolescents and Adults With Type 1 Diabetes: Triple Tracer Mixed Meal Study. J Clin Endocrinol Metab. Published 22 August 2024. doi:10.
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