Possible correlation between Triglyceride/HDL ratio and subclinical myocardial damage in patients with cardiovascular risk factors
Main finding · Pathological GLS per one-unit increase in TG/HDL-C ratioResult — go to the resultCrude odds ratio 1.61Authors' conclusion
In conclusion, patients with elevated TG/HDL-C ratios exhibit subclinical myocardial dysfunction even in the absence of clinical symptoms. The TG/HDL-C ratio may represent a simple marker for early identification of CV risk.
Study context
- Population
- Patients with cardiovascular risk factors who underwent oral glucose tolerance test (OGTT)
- Participants
- 545 patients
- Exposure
- TG/HDL-C ratio quartiles
- Outcome
- Correlation of TG/HDL-C ratio with subclinical myocardial damage
Main finding
As reported in the abstract
Pathological GLS per one-unit increase in TG/HDL-C ratio
Crude odds ratio
1.61
- LV global systolic function (global longitudinal strain (GLS)) showed progressive deterioration across TG/HDL-C quartiles
- P < 0.001
Observational data: associations, not effects.
Further findings
Glucose metabolism across TG/HDL-C quartiles
- Significant increases in fasting plasma glucose (FPG), 2-hour glucose, fasting plasma insulin, 2-hour insulin from first to fourth quartile
- all p < 0.001
- Reduction in insulin sensitivity
Original publication
Possible correlation between Triglyceride/HDL ratio and subclinical myocardial damage in patients with cardiovascular risk factors. Diabetes Res Clin Pract. Published 28 August 2025. doi:10.
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