Positive association of triglyceride-glucose index with new-onset hypertension among adults: a national cohort study in China
Authors' conclusion
High TyG index was significantly associated with an increased risk of new-onset hypertension among Chinese adults. Our findings suggest that maintaining a relatively low level of TyG index might be effective in the primary prevention of hypertension.
Study context
- Population
- Chinese adults with at least 2 rounds of visits 2009–2015 in the China Health and Nutrition Survey; mean age 48.1 (SD 13.6) years, 44.7% men; mean triglyceride-glucose (TyG) index 8.6 (SD 0.7)
- Participants
- 4,600 adults
- Exposure
- TyG index quartiles Q2–Q4 vs Q1
- Outcome
- New-onset hypertension
- Follow-up
- Median 6.0 (IQR 2.0-6.1) years
Methodological detailsnational cohort, China Health and Nutrition Survey
- National cohort
- China Health and Nutrition Survey
Main finding
As reported in the abstract
median follow-up 6.0 years
Adjusted hazard ratio (95% CI)
Q2vs Q1
1.29(1.07–1.55)
Q3vs Q1
1.24(1.03–1.49)
Q4vs Q1
1.50(1.22–1.84)
Per 1.0 increase in TyG indexTyG index as continuous variable; 17% increase in risk
1.17(1.04–1.31)
- Overall new-onset hypertension
- 1,211 (26.3%)
Observational data: associations, not effects.
Further findings
- Associations consistent in various subgroups and sensitivity analysis
Original publication
Positive association of triglyceride-glucose index with new-onset hypertension among adults: a national cohort study in China. Cardiovasc Diabetol. Published 16 March 2023. doi:10.
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