Positive association between stress hyperglycemia ratio and pulmonary infection in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention
Main finding · Pulmonary infection during hospitalizationResult — go to the resultOdds ratio 1.46 95% CI 1.06–2.02Authors' conclusion
The SHR is independently associated with the risk of pulmonary infection during hospitalization and in-hospital MACEs for patients with STEMI undergoing PCI.
Study context
- Population
- Patients with STEMI undergoing percutaneous coronary intervention (PCI), consecutively enrolled 2010–2020
- Participants
- 2,841 patients
- Exposure
- Stress hyperglycemia ratio (SHR) tertiles
- Outcome
- Pulmonary infection
- Follow-up
- During hospitalization
Methodological detailsconsecutively enrolled, multivariate logistic regression
- Consecutively enrolled
- Multivariate logistic regression
Main finding
Pulmonary infection during hospitalization
Odds ratio
1.46
95% CI 1.06–2.02
P = 0.021
SHR
OR 1.46 (95% CI 1.06–2.02); P = 0.021
As reported in the abstract
- Higher SHR associated with higher rate of pulmonary infection across SHR tertiles
- 8.1%, 9.9%, and 18.0%, P < 0.001
- Overall pulmonary infection
- 323 (11.4%)
- No significant non-linear relationship between SHR and pulmonary infection (cubic spline)
- P = 0.210
Observational data: associations, not effects.
Secondary outcomes
In-hospital MACE (all-cause mortality, stroke, target vessel revascularization or recurrent MI)
| OR (95% CI) | P value | ||
|---|---|---|---|
| SHR | 1.67 (1.17–2.39) | P = 0.005 | |
| 0.512Odds ratio (log scale) |
- In-hospital MACE (all-cause mortality, stroke, target vessel revascularization or recurrent MI) — Higher SHR associated with higher rate of in-hospital MACE across SHR tertiles
- 3.7%, 5.1%, and 8.6%, P < 0.001
- In-hospital MACE (all-cause mortality, stroke, target vessel revascularization or recurrent MI) — Overall in-hospital MACE
- 165 (5.8%)
- In-hospital MACE (all-cause mortality, stroke, target vessel revascularization or recurrent MI) — No significant non-linear relationship between SHR and MACE (cubic spline)
- P = 0.743
- In-hospital MACE (all-cause mortality, stroke, target vessel revascularization or recurrent MI): multivariate logistic regression, adjusted for potential confounding factors
Best ROC cutoff of SHR for pulmonary infection
- Best cutoff value of SHR for pulmonary infection
- 1.073
Original publication
Positive association between stress hyperglycemia ratio and pulmonary infection in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. Cardiovasc Diabetol. Published 31 March 2023. doi:10.
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