Gestational diabetes & diabetes in pregnancy
Polyendocrine Metabolic Ovarian Syndrome and the Entire Spectrum of Gestational Dysglycemia: A Population‐Based Cohort Study
Authors' conclusion
Women with PMOS, and particularly those with concomitantly high BMI, constitute a high-risk subgroup for subthreshold gestational dysglycemia and GDM
Study context
- Population
- Women with Israeli military pre-recruitment medical evaluation (ages 16–19) and Maccabi Healthcare Services records, with two-step gestational diabetes mellitus (GDM) screening during first pregnancy, 2001–20197.7% with polyendocrine metabolic ovarian syndrome (PMOS)
- Participants
- 177,241 women
- Exposure
- Women with PMOS vs without PMOS
- PMOSn = 13,648
- Outcome
- Gestational glycaemic category: normoglycemia, abnormal glucose challenge test (GCT) with normal oral glucose tolerance test (OGTT), gestational impaired glucose tolerance (GIGT) and GDM
- Follow-up
- First pregnancy
Methodological detailspopulation-based, routinely collected linked data, universally screened population, multivariable logistic models
- Population-based
- Routinely collected linked data
- Universally screened population
- Multivariable logistic models
Main finding
As reported in the abstract
Gestational dysglycemia
PMOS vs No PMOSAdjusted odds ratio (95% CI)
Abnormal GCT with normal OGTT
1.18(1.11–1.26)
GIGT
1.26(1.16–1.37)
GDM
1.61(1.49–1.73)
Any dysglycemia
1.31(1.25–1.37)
Observational data: associations, not effects.
Further findings
Interaction PMOS × adolescent BMI: PMOS with high adolescent BMI
| aOR (95% CI) | ||
|---|---|---|
| PMOS + high adolescent BMI | 1.77 (1.52–2.10) | |
| 0.512Adjusted odds ratio (log scale) |
- An interaction was observed with the highest odds among women with both PMOS and high adolescent BMI
Original publication
Polyendocrine Metabolic Ovarian Syndrome and the Entire Spectrum of Gestational Dysglycemia: A Population‐Based Cohort Study. Diabetes Obes Metab. Published 17 August 2026. doi:10.
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