PM2.5 exposure, glycemic markers and incidence of type 2 diabetes in two large Indian cities
Authors' conclusion
We observed evidence of temporal association between PM2.5 exposure, and higher FPG and incident T2DM in two urban environments in India, thus highlighting the potential for population-based mitigation policies to reduce the growing burden of diabetes.
Study context
- Population
- Adults in urban Chennai and Delhi, India
- Participants
- 12,064 adults
- Exposure
- Per 10 μg/m³ difference in ambient PM2.5 exposure
- Outcome
- Association of PM2.5 (per 10 μg/m³) with FPG, HbA1c and incident T2D
Methodological detailstwo-city, meta-analytic pooling of city estimates, mixed-effects models, proportional hazards models
- Two-city
- Meta-analytic pooling of city estimates
- Mixed-effects models
- Proportional hazards models
Main finding
As reported in the abstract
Fasting plasma glucose (FPG) increase per 10 μg/m³ difference in monthly average PM2.5
0.40
mg/dL; 95% CI 0.22 to 0.58
HbA1c increase per 10 μg/m³ difference in monthly average PM2.5
0.021
unit; 95% CI 0.009 to 0.032
Risk of incident T2D per 10 μg/m³ difference in annual average PM2.5 (times increased risk; 95% CI 1.09 to 1.36), non-linear exposure response
1.22
Observational data: associations, not effects.
Original publication
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