Plasma miRNAs and Treatment Failure in Participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study
Authors' conclusion
miR-483-3p and miR-4306 may be associated with treatment failure in youth with T2D.
Study context
- Population
- Youth with T2D in the TODAY study; mean age 14.5 years, 62% female
- Participants
- 209 participants
- Primary endpoint
- Treatment failure predicted by a panel of plasma miRNAs
Methodological detailstraining/test data sets
- Training/test data sets
Primary result
As reported in the abstract
Treatment failure
miR-4306, per doubling: decrease in failure
12%
P = 0.040
miR-483-3p, per doubling: marginal increase in failure
12%
P = 0.080
Addition of both miRNAs improved model fit (log likelihood without vs with miRNAs)
−360.3 vs −363.5
P = 0.040
Original publication
Plasma miRNAs and Treatment Failure in Participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study. Diabetes Care. Published 28 December 2023. doi:10.
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