Plasma Branched-Chain Amino Acid and Cardiovascular Disease Risk Factors: A Longitudinal Analysis of a Lifestyle Trial
Authors' conclusion
Increasing levels of BCAAs were associated with insulin resistance, inflammation, and unfavorable lipid profiles, indicating their potential as targets for CVD prevention. Further research is warranted to elucidate how individual BCAAs influence lipid metabolism.
Study context
- Population
- Men and women aged 25 to 78 in the US PREMIER lifestyle trial (lifestyle advice or comprehensive counseling on diet, physical activity and weight loss); NHLBI BioLINCC data
- Participants
- 708 men
- Primary endpoint
- Changes in cardiometabolic risk factors in relation to changes in BCAA levels (per 1 SD)
- Follow-up
- 6 months
Methodological detailsPREMIER, false discovery rate-adjusted Q values, Biomarkers measured by nuclear magnetic resonance spectroscopy at baseline and 6 months; linear regression
- PREMIER
- False discovery rate-adjusted Q values
- Biomarkers measured by nuclear magnetic resonance spectroscopy at baseline and 6 months; linear regression
Primary result
As reported in the abstract
Association of BCAA increase (per 1 SD) with cardiovascular diseases (CVD) risk factor changes
HOMA-IR (β, SE 0.07)
0.22
Glycoprotein acetylation (β, SE 0.004)
0.03 mmol/L
Apolipoprotein B (β, SE 0.006)
0.02 g/L
VLDL cholesterol (β, SE 0.007)
0.03 mmol/L
Original publication
Plasma Branched-Chain Amino Acid and Cardiovascular Disease Risk Factors: A Longitudinal Analysis of a Lifestyle Trial. J Clin Endocrinol Metab. Published 16 September 2025. doi:10.
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