Plant‐based dietary patterns and genetic susceptibility to obesity in the CARTaGENE cohort
Authors' conclusion
These findings suggest that components of a plant-based diet and a shift away from animal products, specifically meat, might be beneficial for nutrition interventions, particularly among individuals with higher genetic risk of obesity.
Study context
- Population
- Adults from the CARTaGENE cohort of Quebec adults (57% women, aged 55.6 ± 7.7 years); follow-up obesity outcomes measured 6 years later2,258 at follow-up
- Participants
- 7,037 adults
- Outcome
- Whether adherence to three PDIs (overall, healthy, unhealthy) mediated or moderated genetic susceptibility to obesity (polygenic risk scores for BMI (PRS-BMI))
Methodological detailscross-sectional and longitudinal analyses, causal mediation analysis
- Cross-sectional and longitudinal analyses
- Causal mediation analysis
Main finding
As reported in the abstract
Mediation/moderation of genetic susceptibility to obesity by PDI adherence
- Adherence to PDIs did not mediate or moderate genetic susceptibility to obesity
- Overall- and healthy-PDIs and PRSs were significantly associated with obesity outcomes
Observational data: associations, not effects.
Further findings
Mediation by food components
- PRS–obesity associations partly mediated by meat intake cross-sectionally and by whole grains intake among males both cross-sectionally and longitudinally
- Higher meat intake positively associated, higher whole grains intake inversely associated with obesity outcomes
Original publication
Plant‐based dietary patterns and genetic susceptibility to obesity in the CARTaGENE cohort. Obesity (Silver Spring). Published 6 December 2023. doi:10.
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