PIONEER REAL Saudi Arabia: A multicentre, prospective, real‐world study of once‐daily oral semaglutide use in adults with type 2 diabetes in Saudi Arabia
Authors' conclusion
This real-world population of adults with T2D in Saudi Arabia experienced clinically significant reductions in HbA1c and BW, increased treatment satisfaction and a favourable safety profile, consistent with previously published PIONEER REAL studies.
Study context
- Population
- Adults with T2D, treatment-naive to injectable glucose-lowering medication, Saudi Arabia; baseline mean age 51.7 years, mean HbA1c 8.0%, mean body weight (BW) 90.5 kg139 completed
- Participants
- 192 adults
- Outcome
- Change in HbA1c from baseline to end of study (EoS)
- Follow-up
- 34–44 weeks
Methodological detailsmulticentre, open-label, single-arm
- Multicentre
- Open-label
- Single-arm
Main finding
As reported in the abstract
Change in HbA1c from baseline to EoS · EoS (34–44 weeks)
Estimated mean change in HbA1c (SE 0.09; p < 0.0001)
−1.0%-points
Observational data: associations, not effects.
Further findings
Change in BW from baseline to end of study (EoS)
- Estimated mean change in BW (SE 0.51; p < 0.0001)
- −4.4 kg
Change in waist circumference (WC) from baseline to EoS
- Estimated mean change in WC (SE 0.62; p < 0.0001)
- −4.3 cm
HbA1c <7% · EoS
- Participants with HbA1c <7%
- 61.9%
HbA1c reduction ≥1% with BW reduction ≥3% or ≥5% · EoS
- HbA1c ↓≥1% and BW ↓≥3%
- 21.9%
- HbA1c ↓≥1% and BW ↓≥5%
- 17.1%
Treatment satisfaction · EoS
- Mean change in Diabetes Treatment Satisfaction Questionnaire-status (DTSQs) (p < 0.0001)
- +8.7
- Mean change in DTSQc (p < 0.0001)
- 14.9
Remaining on oral semaglutide · EoS
- Remained on oral semaglutide
- 49.5%
- Of those, receiving 14.0 mg dose
- 47.4%
Original publication
PIONEER REAL Saudi Arabia: A multicentre, prospective, real‐world study of once‐daily oral semaglutide use in adults with type 2 diabetes in Saudi Arabia. Diabetes Obes Metab. Published 27 November 2025. doi:10.
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